Login / Signup

Electrochemical Difluoromethylation of Electron-Rich Olefins.

Shinan LuanThomas CastanheiroThomas Poisson
Published in: Organic letters (2023)
The electrochemical difluoromethylation of electron-rich olefins (enamides and styrene derivatives) is disclosed. The addition of the electrogenerated difluoromethyl radical from the corresponding sodium sulfinate (i.e., HCF 2 SO 2 Na) to enamides and styrenes in an undivided cell allowed the formation of a large panel of difluoromethylated building blocks in good to excellent yields (42 examples, 23-87% yields). A plausible unified mechanism was suggested according to control experiments and cyclic voltammetry measurements.
Keyphrases
  • gold nanoparticles
  • electron transfer
  • molecularly imprinted
  • ionic liquid
  • label free
  • single cell
  • solar cells
  • cell therapy
  • stem cells