Profiling of circulating chromosome 21-encoded microRNAs, miR-155, and let-7c, in down syndrome.
Jesús Manuel Pérez-VillarrealKatia Aviña-PadillaEvangelina Beltrán-LópezAlma Marlene Guadrón-LlanosEsther López-BayghenJavier Magaña-GómezMarco Antonio Meraz-RíosAlfredo Varela-EchavarríaCarla E. Angulo RojoPublished in: Molecular genetics & genomic medicine (2022)
Overall, our results suggest that let-7c plays a role from the early stages of DS's cognitive impairment while overexpression of miR-155 may be related to lipid metabolism changes. Further studies of both miRNAs will shed light on their potential as therapeutic targets to prevent or delay DS's cognitive impairment.