Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA.
Reshma JagsiKent A GriffithEleanor E R HarrisJean L WrightAbram RechtAlphonse G TaghianLucille LeeMeena S MoranWilliam SmallCandice JohnstoneAsal RahimiGary FreedmanMahvish MuzaffarBruce George HafftyKathleen HorstSimon N PowellJody SharpMichael SabelAnne SchottMahmoud El-TamerPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
This trial achieved a very low risk of recurrence using a genomic assay in combination with classic clinical and biologic features for treatment selection, including postmenopausal patients younger than 60 years. Long-term follow-up of this trial and others will help determine whether the option of avoiding initial radiotherapy can be offered to a broader group of women than current guidelines recommend.
Keyphrases
- end stage renal disease
- early stage
- study protocol
- clinical trial
- chronic kidney disease
- ejection fraction
- minimally invasive
- phase iii
- newly diagnosed
- radiation therapy
- locally advanced
- radiation induced
- copy number
- peritoneal dialysis
- gene expression
- coronary artery bypass
- clinical practice
- adipose tissue
- skeletal muscle
- pregnant women
- insulin resistance
- replacement therapy
- dna methylation
- surgical site infection
- atrial fibrillation
- early breast cancer