Evaluation of Anti- Candida albicans Activity and Release of Ketoconazole in PMMA-G-PEG 4000 Films.
Juliana Ribeiro ReynaldoKátia Monteiro NovackLucas Resende Dutra SousaPaula Melo de Abreu VieiraTatiane Roquete AmparoGustavo Henrique Bianco de SouzaLuiz Fernando Medeiros TeixeiraAna Paula Moreira BarbozaBernardo Ruegger Almeida NevesMeiry Edivirges AlvarengaFelipe Terra MartinsViviane Martins Rebello Dos SantosPublished in: International journal of molecular sciences (2022)
Modified release systems depend on the selection of an appropriate agent capable of controlling the release of the drug, sustaining the therapeutic action over time, and/or releasing the drug at the level of a particular tissue or target organ. Polyethylene glycol 4000 (PEG 4000) is commonly employed in drug release formulations while polymethyl methacrylate (PMMA) is non-toxic and has a good solubility in organic solvents. This study aimed at the incorporation of ketoconazole in PMMA-g-PEG 4000 and its derivatives, thus evaluating its release profile and anti- Candida albicans and cytotoxic activities. Ketoconazole was characterized and incorporated into the copolymers. The ketoconazole incorporated in the copolymer and its derivatives showed an immediate release profile. All copolymers with ketoconazole showed activity against Candida albicans and were non-toxic to human cells in the entire concentration tested.