Promoter methylation, transcription, and retrotransposition of LINE-1 in colorectal adenomas and adenocarcinomas.
Milad ShademanKhadijeh ZareMorteza ZahediHooman Mosannen MozaffariHadi Bagheri HosseiniKamran GhaffarzadeganLadan GoshayeshiHesam DehghaniPublished in: Cancer cell international (2020)
Our correlative analysis showing a decreased methylation of LINE-1 promoter accompanied by the higher level of LINE-1 transcription, and polymorphic genomic insertions in advanced adenoma, suggests that the early and advanced polyp stages may host very important pathogenic processes concluding to cancer.