Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis.

Hanna BonnekohCarolina VeraAngela Abad-PerezSilke RadetzkiMartin NeuenschwanderEdgar SpeckerNiklas Amadeus MahnkeStefan FrischbutterEicke LatzMarc NazaréJens V KriesMarcus MaurerJörg ScheffelKaroline Krause

Published in: Clinical and translational allergy (2021)

We show that disulfiram is a dose-dependent inhibitor of inflammasome pathway activation in vitro and inhibitor of SDS-induced eczema in vivo. Topical application of disulfiram represents a potential treatment option for irritant contact dermatitis.

Keyphrases

high glucose
wound healing
diabetic rats
drug induced
combination therapy
replacement therapy