Isolation of a high-affinity Bet v 1-specific IgG-derived ScFv from a subject vaccinated with hypoallergenic Bet v 1 fragments.
E GadermaierK MarthC LupinekR CampanaG HoferK BlattDubravka SmiljkovicU RoderM Focke-TejklS VrtalaWalter KellerP ValentRudolph ValentaSabine FlickerPublished in: Allergy (2018)
Immunization with unfolded hypoallergenic allergen derivatives induces high-affinity antibodies even in nonallergic subjects which recognize the folded wild-type allergens and inhibit polyclonal IgE binding of allergic patients.