Bone mineralization and vascularization in bisphosphonate-related osteonecrosis of the jaw: an experimental study in the rat.

Jean-Daniel Kün-DarboisHélène LiboubanGuillaume MabilleauFlorence Pascaretti-GrizonDaniel Chappard

Published in: Clinical oral investigations (2018)

Prolonged BP administration caused an increase in the mineralization and a quantitative reduction of the vascularization in the alveolar bone; both factors might be involved concomitantly in the BRONJ pathophysiology.

Keyphrases

bone mineral density
soft tissue
bone loss
bone regeneration
tissue engineering
oxidative stress
postmenopausal women
mass spectrometry