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Pho81 is a novel regulator of pexophagy induced by phosphate starvation.

Yuxiang HuangDaniel J Klionsky
Published in: Autophagy (2024)
In the budding yeast Saccharomyces cerevisiae , macroautophagy/autophagy can be induced by various types of starvation. It is thought that potential autophagic substrates vary to meet specific nutritional demands under different starvation conditions. In a recent study, Gross et al . found that autophagy induced by phosphate starvation includes many selective aspects. For example, this work identified Pho81 as a regulator of pexophagy under conditions of phosphate starvation. Pho81 senses phosphate metabolites and directly interacts with Atg11 to promote Atg1-mediated Atg11 phosphorylation. This finding provides an example of how modulation of the Atg1/ULK kinase complex can convey specific metabolic information to regulate autophagic substrates. Abbreviation : AKC: Atg1/ULK kinase complex.
Keyphrases
  • saccharomyces cerevisiae
  • cell death
  • protein kinase
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • transcription factor
  • healthcare
  • binding protein
  • risk assessment
  • social media
  • human health