The effects of kisspeptin on β-cell function, serum metabolites and appetite in humans.
Chioma Izzi-EngbeayaAlexander N ComninosSophie A ClarkeAnne JomardLisa YangSophie JonesAli AbbaraShakunthala NarayanaswamyPei Chia EngDeborah PapadopoulouJulia K PraguePaul BechIan F GodslandPaul BassettCaroline SandsStephane CamuzeauxMaria Gomez-RomeroJake T M PearceMatthew R LewisElaine HolmesJeremy K NicholsonTricia TanRisheka RatnasabapathyMing HuGaelle CarratLorenzo PiemontiMarco BuglianiPiero MarchettiPaul R JohnsonStephen J HughesA M James ShapiroGuy A RutterWaljit Singh DhilloPublished in: Diabetes, obesity & metabolism (2018)
Collectively, these data demonstrate for the first time a beneficial role for kisspeptin in insulin secretion in humans in vivo. This has important implications for our understanding of the links between reproduction and metabolism in humans, as well as for the ongoing translational development of kisspeptin-based therapies for reproductive and potentially metabolic conditions.