Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly.

Leonard Daniël SamsonPeter EngelfrietW M Monique VerschurenH Susan J PicavetJosé A FerreiraMary-Lène de Zeeuw-BrouwerAnne-Marie BuismanA Mieke H Boots

Published in: Immunity & ageing : I & A (2022)

Our results emphasize the importance of preserved JAK-STAT pathway signaling in healthy aging and reveal cellular pSTAT levels as a candidate biomarker of frailty.

Keyphrases

community dwelling
genome wide
middle aged
peripheral blood