Increased Activity of MAPKAPK2 within Mesenchymal Cells as a Target for Inflammation-Associated Fibrosis in Crohn's Disease.

Marina ChulkinaChristina RohmerSteven McAninchRonaldo Paolo PanganibanRomain VillégerAustin PortoleseJustin CiocirlanWenjing YangClaire CohenWalter KoltunJohn F ValentineYingzi CongGregory YochumEllen J BeswickIrina V Pinchuk

Published in: Journal of Crohn's & colitis (2024)

Our data suggest that activation of MK2 within fibroblasts contributes to the chronic inflammation-induced fibrosis in CD and that targeting MK2 has potential for the development of novel therapeutic approaches for fibrosis in CD.

Keyphrases

oxidative stress
induced apoptosis
stem cells
liver fibrosis
cell cycle arrest
high glucose
drug induced
nk cells
big data
cancer therapy
drug delivery
signaling pathway
human health