Feasibility and tolerability of trofosfamide and etoposide in progressive glioblastoma.

Teresa SchmidtSarina AgkatsevJonas FeldheimChristoph OsterTobias BlauUlrich SureKathy KeyvaniChristoph KleinschnitzMartin StuschkeKen HerrmannCornelius DeuschlBjörn SchefflerSied KebirMartin GlasLazaros Lazaridis

Published in: Neuro-oncology advances (2023)

This study provides first indication that the combination of trofosfamide plus etoposide is safe in adult glioblastoma patients. The observed survival outcomes might suggest potential beneficial effects. Our data provide a reasonable rationale for follow-up of a larger cohort in a prospective trial.

Keyphrases

end stage renal disease
clinical trial
newly diagnosed
ejection fraction
multiple sclerosis
prognostic factors
open label
study protocol
electronic health record
phase iii
machine learning
risk assessment
patient reported outcomes
young adults
deep learning
data analysis