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Assessing the lack of diversity in genetics research across neurodegenerative diseases: a systematic review of the GWAS Catalog and literature.

Caroline Warly SolsbergKristin S LevineJulie LakeLinnea HertsletLietsel JonesDhairya PatelJeff KimSara Bandres-CigaNancy TerryIgnacio F MataCornelis BlauwendraatAndrew B SingletonMike A NallsJennifer S YokoyamaHampton L Leonard
Published in: medRxiv : the preprint server for health sciences (2024)
Our findings underscore the pressing need for increased diversity in neurodegenerative research. The significant under-representation of non-European ancestry participants in NDD GWAS limits our understanding of the genetic underpinnings of these diseases. To advance the field of neurodegenerative research and develop more effective therapies, it is imperative that future investigations prioritize and harness the genomic diversity present within and across global populations.
Keyphrases
  • systematic review
  • genome wide association study
  • genome wide
  • current status