A genome-wide linkage study of autism spectrum disorder and the broad autism phenotype in extended pedigrees.

Marc R Woodbury-SmithAndrew D PatersonIrene O'ConnorMehdi ZarreiRyan K C YuenJennifer L HoweAnn ThompsonMorgan ParlierBridget FernandezJoseph PivenStephen W SchererVeronica VielandPeter Szatmari

Published in: Journal of neurodevelopmental disorders (2018)

Inclusion of subclinical phenotypes such as BAP should be more widely employed in genetic studies of ASD as a way of identifying inherited genetic variants for the disorder. Moreover, the results underscore the need for approaches to identifying genetic risk factors in extended pedigrees that are robust to high levels of inter/intrafamilial locus and allelic heterogeneity.

Keyphrases

genome wide
autism spectrum disorder
intellectual disability
dna methylation
risk factors
attention deficit hyperactivity disorder
copy number
single cell
gene expression
human immunodeficiency virus
hepatitis c virus
case control
antiretroviral therapy