Development of the Commercial Manufacturing Process for Nirmatrelvir in 17 Months.

Christophe AllaisChristina G ConnorNga M DoSamir KulkarniJohnny W LeeTaegyo LeeEmma L McInturffJared PiperDavid W Place John A RaganR Matt Weekly

Published in: ACS central science (2023)

The advancement of nirmatrelvir, the active ingredient in Paxlovid, from discovery to emergency use authorization was achieved in just 17 months, requiring an unprecedented rate of chemical process development.

Keyphrases

emergency department
public health
healthcare
small molecule
high throughput