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Comparing photon and proton-based hypofractioned SBRT for prostate cancer accounting for robustness and realistic treatment deliverability.

Lee C GoddardN Patrik BrodinWilliam R BodnerMadhur K GargWolfgang Axel Tomé
Published in: The British journal of radiology (2018)
Similar treatment plans can be generated with IMPT compared to VMAT in terms of target coverage, target conformality, and OAR sparing when range and HU uncertainties are neglected. However, when accounting for these uncertainties during robust optimization, VMAT outperforms IMPT in terms of achievable target conformity and OAR sparing. Advances in knowledge: Comparison between achievable dose distributions using modern, robust optimization of IMPT for high dose per fraction SBRT regimens for the prostate has not been previously investigated.
Keyphrases
  • prostate cancer
  • high dose
  • healthcare
  • low dose
  • robot assisted
  • radical prostatectomy
  • combination therapy
  • replacement therapy
  • high resolution
  • single molecule
  • smoking cessation
  • fluorescent probe