Fumagillin Attenuates Spinal Angiogenesis, Neuroinflammation, and Pain in Neuropathic Rats after Chronic Constriction Injury.

Zhi-Hong Wen Shi-Ying Huang Hsiao-Mei KuoChao-Ting ChenNan-Fu ChenWu-Fu ChenKuan-Hao TsuiHsin-Tzu LiuChun-Sung Sung

Published in: Biomedicines (2021)

Fumagillin significantly ameliorates CCI-induced nociceptive sensitization, spinal angiogenesis, and astrocyte activation. Our results suggest that angiogenesis inhibitor treatment suppresses peripheral neuropathy-induced central angiogenesis, neuroinflammation, astrocyte activation, and neuropathic pain.

Keyphrases

neuropathic pain
spinal cord
endothelial cells
high glucose
spinal cord injury
vascular endothelial growth factor
diabetic rats
traumatic brain injury
lipopolysaccharide induced
drug induced
signaling pathway
chronic pain
mouse model
replacement therapy
smoking cessation