Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma.

Feng ZhangWenfeng LiuFansheng MengQiuyu JiangWenqing TangZhiyong LiuXiahui LinRuyi XueSi ZhangLing Dong

Published in: Journal for immunotherapy of cancer (2024)

Macrophage-specific PLA2G7 serves as a novel biomarker capable of prognosticating immunotherapy responsiveness and inhibiting PLA2G7 has the potential to enhance the efficacy of ICB therapy for HCC.

Keyphrases

signaling pathway
adipose tissue