An RSV live-attenuated vaccine candidate lacking G protein mucin domains is attenuated, immunogenic, and effective in preventing RSV in BALB/c mice.

Molly K RoeMaria A PerezHui-Mien HsiaoStacey A LappHe-Ying SunSamadhan JadhaoAudrey R YoungYara S BatistaRyan C ReedAzmain TazPardis SabetiXuemin ChenBo LiangMichael KovalTimothy A SniderMartin L MooreLarry J AndersonLarry J AndersonChristopher C StobartChristina A Rostad

Published in: The Journal of infectious diseases (2022)

Removal of the G-protein mucin domains produced RSV LAV candidates that were highly attenuated with retained immunogenicity.

Keyphrases

respiratory syncytial virus
respiratory tract
high fat diet induced
type diabetes
wild type