Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer.

Nuramalina H MuminNeele DrobnitzkyAgata PatelLuiza Madia LourencoFiona F CahillYanyan JiangAnthony KongAnderson J Ryan

Published in: BMC cancer (2019)

Acquired resistance to HSP90i in TNBC cells is associated with an upregulated JAK-STAT signalling pathway. A combined inhibition of the JAK-STAT signalling pathway and HSP90 could overcome this resistance. The benefits of the combined therapy could be explored further for the development of effective targeted therapy in TNBC patients.

Keyphrases

heat shock protein
heat shock
heat stress
end stage renal disease
induced apoptosis
ejection fraction
newly diagnosed
stem cells
patient reported outcomes
oxidative stress
cell proliferation
mesenchymal stem cells
signaling pathway
cell therapy
pi k akt