The Biological Role of Pleural Fluid PAI-1 and Sonographic Septations in Pleural Infection: Analysis of a Prospectively Collected Clinical Outcome Study.
Eihab O BedawiNikolaos I KanellakisJohn P CorcoranYu ZhaoMaged HassanRachelle AsciakRachel M MercerAnand SundaralingamDinesh N AddalaRobert F MillerTao DongAlison M CondliffeNajib M RahmanPublished in: American journal of respiratory and critical care medicine (2022)
In a large and well characterised cohort, this is the first study to associate pleural biological parameters with a validated sonographic septation outcome in pleural infection. PF PAI-1 is the first biomarker to demonstrate an independent association with mortality. While PF PAI-1 plays an integral role in driving septation formation, septations themselves are not associated with clinically important outcomes. These novel findings now require prospective validation.