FAM83A promotes the progression and metastasis of human pancreatic neuroendocrine tumors by inducing the epithelial-mesenchymal transition via the PI3K/AKT and ERK pathways.

B ZhouX ZhouC ZhanM JinSheng Yan

Published in: Journal of endocrinological investigation (2022)

FAM83A plays an important role in the progression and metastasis of PanNET by inducing the EMT via the activation of the ERK and PI3K/AKT pathways and may serve as a valuable molecular target in PanNET treatment.

Keyphrases

pi k akt
signaling pathway
epithelial mesenchymal transition
neuroendocrine tumors
cell proliferation
cell cycle arrest
transforming growth factor
endothelial cells
induced pluripotent stem cells
single molecule