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Spinal cord atrophy predicts progressive disease in relapsing multiple sclerosis.

Antje BischofNico PapinuttoAnisha KeshavanAnand RajeshGina KirkishXinheng ZhangJacob M MallottCarlo AsteggianoSimone SaccoTristan J GundelChao ZhaoWilliam A SternEduardo CaverzasiYifan ZhouRefujia GomezNicholas R RaganAdam SantanielloAlyssa H ZhuJeremy JuwonoCarolyn J BevanRiley M BoveElizabeth CrabtreeJeffrey M GelfandDouglas S GoodinJennifer S GravesAri J GreenJorge R OksenbergEmmanuelle WaubantMichael R WilsonScott S Zamvilnull nullBruce Anthony Campbell CreeStephen L HauserRoland G Henry
Published in: Annals of neurology (2021)
Silent progression and conversion to secondary progressive disease are predominantly related to cervical cord atrophy. This atrophy is often present from the earliest disease stages and predicts the speed of silent progression and conversion to Progressive MS. Diagnosis of SPMS is rather a late recognition of this neurodegenerative process than a distinct disease phase. This article is protected by copyright. All rights reserved.
Keyphrases
  • multiple sclerosis
  • spinal cord
  • white matter
  • mass spectrometry
  • spinal cord injury