A Promising Biomolecule Able to Degrade Neutrophil Extracellular Traps: Cdc PDE, a Rattlesnake Phosphodiesterase.

Neutrophil extracellular traps (NETs) are an important mechanism for defense against pathogens. Their overproduction can be harmful since excessive NET formation promotes inflammation and tissue damage in several diseases. Nucleases are capable to degrade NET on basis of their DNA hydrolysis activity, including the Cdc PDE, a nuclease isolated from Crotalus durissus collilineatus snake venom. Here, we report a new finding about Cdc PDE activity, demonstrating its efficiency in degrading cell-free DNA from NETs, being a potential candidate to assist in therapies targeting inflammatory diseases.