Antileukemic Activity of Twig Components of Caucasian Beech in Turkey.
Wataru ShidaHiroshi TateishiYurika TaharaMikako FujitaDoaa H M AlsaadiMasato WatanabeRyoko KogaMohamed Osman RadwanHalilibrahim ÇiftçiSevgi GeziciYuki KurauchiHiroshi KatsukiMasami OtsukaKoji SugimuraMikiyo WadaNazim SekerogluTakashi WatanabePublished in: Molecules (Basel, Switzerland) (2019)
Despite the development of a range of anti-cancer agents, cancer diagnoses are still increasing in number, remaining a leading cause of death. Anticancer drug treatment is particularly important for leukemia. We screened Turkish plants and found the unique antileukemic activity of twig components in Turkish Caucasian beech, selectively inducing apoptosis in leukemia cells. This effect is unique among some kinds of beeches, presumably related to oxidative stress. This study would lead to effective use of discarded material, i.e., twig of beech, and a new anti-leukemic drug based on large tree.
Keyphrases
- oxidative stress
- induced apoptosis
- cell cycle arrest
- acute myeloid leukemia
- endoplasmic reticulum stress
- bone marrow
- cell death
- papillary thyroid
- african american
- pi k akt
- dna damage
- drug induced
- ischemia reperfusion injury
- emergency department
- diabetic rats
- squamous cell
- lymph node metastasis
- childhood cancer
- replacement therapy