Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion.
Alvin Kunyao GuoYoko ItahanaVeerabrahma Pratap SeshachalamHui Ying ChowSujoy GhoshKoji ItahanaPublished in: British journal of cancer (2020)
The interaction between TP53R273H and BCAR1 plays an important role in enhancing cancer cell invasion. Thus, our study suggests a disruption of the TP53R273H-BCAR1 binding as a potential therapeutic approach for TP53R273H-harbouring cancer patients.