Tumor necrosis factor-inducible gene 6 protein and its derived peptide ameliorate liver fibrosis by repressing CD44 activation in mice with alcohol-related liver disease.

Jinsol HanChanbin LeeHayeong JeongSeunghee JeonMyunggyo LeeHaeseung LeeYung Hyun ChoiYoungmi Jung

Published in: Journal of biomedical science (2024)

These results demonstrate that TSG-6 attenuates alcohol-induced liver damage and fibrosis by blocking CD44 cleavage to CD44ICD and suggest that TSG-6 and TSG-6-mimicking peptide could be used as therapeutics for ALD with fibrosis.

Keyphrases

liver fibrosis
nk cells
rheumatoid arthritis
oxidative stress
type diabetes
genome wide
diabetic rats
high glucose
gene expression
copy number
dna methylation
skeletal muscle
high fat diet induced
amino acid
dna binding
transcription factor
insulin resistance