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Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients.

A Joseph BloomXianrong MaoAmy StricklandYo SasakiJeffrey MilbrandtAaron DiAntonio
Published in: Molecular neurodegeneration (2022)
These results implicate rare hypermorphic SARM1 alleles as candidate genetic risk factors for ALS and other neurodegenerative conditions.
Keyphrases
  • end stage renal disease
  • newly diagnosed
  • copy number
  • amyotrophic lateral sclerosis
  • prognostic factors
  • genome wide
  • patient reported outcomes
  • patient reported