Sevoflurane preconditioning promotes mesenchymal stem cells to relieve myocardial ischemia/reperfusion injury via TRPC6-induced angiogenesis.
Jinting YangLihui TangFengjiang ZhangTingting YangTing LuKai SunNa SunJinxuan RenXianwei ChePublished in: Stem cell research & therapy (2021)
The current findings reveal that sevoflurane preconditioned MSCs boost angiogenesis in HUVECs subjected to H/R insult and attenuate myocardial I/R injury, which may be mediated by TRPC6 up-regulated HIF-1α, CXCR4 and VEGF.
Keyphrases
- endothelial cells
- ischemia reperfusion injury
- mesenchymal stem cells
- high glucose
- vascular endothelial growth factor
- umbilical cord
- left ventricular
- oxidative stress
- vascular smooth muscle cells
- diabetic rats
- bone marrow
- transcription factor
- cell therapy
- genome wide
- wound healing
- single cell
- heart failure
- stem cells
- brain injury
- drug induced
- cell migration
- gene expression
- atrial fibrillation
- cerebral ischemia
- subarachnoid hemorrhage