Maturation of Paracetamol Elimination Routes in Preterm Neonates Born Below 32 Weeks of Gestation.

Yunjiao WuSwantje VöllerElke H J KrekelsDaniëlla W E RoofthooftSinno H P SimonsDick TibboelRobert B FlintCatherijne A J Knibbe

Published in: Pharmaceutical research (2023)

Birthweight and PNA are the most important predictors for maturational changes in paracetamol clearance and its glucuronidation, sulfation and oxidation. As a result, dosing based on bodyweight alone will not lead to consistent paracetamol concentrations among preterm neonates.

Keyphrases

gestational age
low birth weight
preterm birth
preterm infants
anti inflammatory drugs