Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk.
Nikhil K KhankariBarbara L BanburyMaria-Carolina BorgesPhilip C HaycockDemetrius AlbanesVolker ArndtSonja I BerndtStéphane BézieauHermann BrennerPeter T CampbellGraham CaseyAndrew T ChanJenny Chang-ClaudeDavid V ContiMichelle CotterchioDallas R EnglishJane C FigueiredoGraham G GilesEdward L GiovannucciMarc J GunterJochen HampeMichael HoffmeisterJohn L HopperMark A JenkinsAmit D JoshiLoic Le MarchandMathieu LemireChristopher I LiLi LiAnnika LindblomVicente Martín SánchezVictor MorenoPolly A NewcombKenneth OffitPaul David Peter PharoahGadi RennertLori C SakodaClemens SchafmayerStephanie L SchmitMartha L SlatteryMingyang SongStephen N ThibodeauCornelia M UlrichStephanie J WeinsteinEmily WhiteAung-Ko WinAlicja WolkMichael O WoodsAnna H WuQiuyin CaiJoshua C DennyTodd L EdwardsHarvey J MurffStephen B GruberUlrike PetersWei ZhengPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2020)
The interaction of PUFAs with aspirin/NSAID use indicates a shared colorectal cancer inflammatory pathway. Future research should continue to improve PUFA genetic instruments to elucidate the independent effects of PUFAs on colorectal cancer.