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A theranostic saponin nano-assembly based on FRET of an aggregation-induced emission photosensitizer and photon up-conversion nanoparticles.

Hao FuYongkang HuangHongguang LuJinxia AnDe-E LiuYongxin ZhangQixian ChenHui Gao
Published in: Journal of materials chemistry. B (2020)
A photodynamic aggregation-induced emissive (AIE) fluorophore, characterized by near-infrared (NIR) emission, was created based on a fluorescence resonance energy transfer (FRET) donor of appreciable NIR up-conversion nanoparticles (UCNPs) and acceptor of immense fluorescence emissive AIEgen. Hence, the entrapment of the FRET couple into an amphiphilic saponin-based nanoscaled self-assembly demonstrated appealing theranostic functions in producing immense fluorescence emission and cytotoxic reactive oxygen species (ROS).
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