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Serial Changes in Blood-Cell-Count-Derived and CRP-Derived Inflammatory Indices of COVID-19 Patients.

Maryam B KhadzhievaAlesya S GrachevaOlesya B BelopolskayaYulia V ChursinovaIvan V RedkinMikhail V PisarevArtem N Kuzovlev
Published in: Diagnostics (Basel, Switzerland) (2023)
The aim of the study was to investigate the serial changes in inflammatory indices derived from blood cell counts and C-reactive protein (CRP) levels in COVID-19 patients with good and poor outcomes. We retrospectively analyzed the serial changes in the inflammatory indices in 169 COVID-19 patients. Comparative analyses were performed on the first and last days of a hospital stay or death and serially from day 1 to day 30 from the symptom onset. On admission, non-survivors had higher CRP to lymphocytes ratio (CLR) and multi-inflammatory index (MII) values than survivors, while at the time of discharge/death, the largest differences were found for the neutrophil to lymphocyte ratio (NLR), systemic inflammation response index (SIRI), and MII. A significant decrease in NLR, CLR, and MII by the time of discharge was documented in the survivors, and a significant increase in NLR was documented in the non-survivors. The NLR was the only one that remained significant from days 7-30 of disease in intergroup comparisons. The correlation between the indices and the outcome was observed starting from days 13-15. The changes in the index values over time proved to be more helpful in predicting COVID-19 outcomes than those measured on admission. The values of the inflammatory indices could reliably predict the outcome no earlier than days 13-15 of the disease.
Keyphrases
  • sars cov
  • oxidative stress
  • coronavirus disease
  • young adults
  • emergency department
  • single cell
  • cell therapy
  • peripheral blood
  • metabolic syndrome
  • type diabetes
  • skeletal muscle
  • bone marrow
  • weight loss
  • glycemic control