Tranexamic acid is safe and effective in patients with heterozygous factor V Leiden mutation during total joint arthroplasty.

Ali Levent Ozkan Kose Philip M Linke Thorsten Gehrke Ahmad Shoib Sharqzad

Published in: Archives of orthopaedic and trauma surgery (2021)

The combined local and systemic administration of TXA could be safely used in patients with heterozygous FVL mutation receiving pharmacological thromboprophylaxis during TJA without increasing the risk of VTE.

Keyphrases

venous thromboembolism
early onset
direct oral anticoagulants