NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults.
N J ConnellL GrevendonkC E FealyE Moonen-KornipsY M H BrulsV B Schrauwen-HinderlingJ de VogelR HagemanJ GeurtsR Zapata-PerezR H HoutkooperB HavekesJ HoeksPatrick SchrauwenPublished in: The Journal of nutrition (2022)
Our findings are consistent with previous findings on NAD+ efficacy in humans, and we show in community-dwelling, older adults with impaired physical function that NAD+-precursor supplementation through L-tryptophan, nicotinic acid, and nicotinamide does not improve mitochondrial or skeletal muscle function. This study was registered at clinicaltrials.gov as NCT03310034.