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Alteplase for Stroke With Unknown Onset Time in Chronic Kidney Disease: A Pooled Analysis of Individual Participant Data.

Kaori MiwaMasatoshi KogaMärit JensenManabu InoueSohei YoshimuraMayumi Fukuda-DoiFlorent BoutitieHenry MaPeter Arthur RinglebOna WuLee S SchwammSteven J WarachWerner HackeStephen M DavisGeoffrey Alan DonnanChiristian GerloffGötz ThomallaKazunori Toyodanull null
Published in: Stroke (2022)
The present analysis indicates that the benefit of alteplase does not differ between stroke patients with unknown onset time with and without CKD, although the statistical power was lacking to confirm the efficacy in subgroups. This study only applies to mild-to-moderate or predialysis CKD.
Keyphrases
  • atrial fibrillation
  • chronic kidney disease
  • acute ischemic stroke
  • big data
  • clinical trial
  • brain injury
  • data analysis
  • blood brain barrier
  • study protocol
  • double blind