MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation.

Lochlan J FennellSaara JamiesonDiane McKeoneTracie CorishMegan RohdmannTori FurnerMark BettingtonCheng LiuFutoshi KawamataCatherine BondJolieke Van De PolsBarbara LeggettVicki Whitehall

Published in: BMC cancer (2018)

The MLH1-93 AA genotype is significantly associated with promoter hypermethylation and MLH1 loss in the context of SSADs. BRAF mutant microsatellite stable colorectal cancers with the AA genotype most likely arise in TSAs since the A allele does not predispose to methylation in this context.

Keyphrases

dna methylation
genome wide
gene expression
transcription factor
protein protein
young adults
small molecule
binding protein
metastatic colorectal cancer