A genetic model for central chondrosarcoma evolution correlates with patient outcome.

William CrossIben LyskjærTom LesluyesSteven HargreavesAnna-Christina StroblChristopher DaviesSara WaiseShadi Hames-FathiDahmane OukrifHongtao YeFernanda AmaryRoberto TiraboscoCraig GerrandToby BakerDavid BarnesChristopher SteeleLudmil AlexandrovGareth Bondnull nullPaul CoolNischalan PillayPeter Van LooAdrienne M Flanagan

Published in: Genome medicine (2022)

Tumours with IDH1 or IDH2 mutations or those that are IDHwt have significantly different genetic pathways and outcomes in relation to TERT mutation. Diagnostic testing for IDH1, IDH2, and TERT mutations could therefore help to guide clinical monitoring and prognostication.

Keyphrases

low grade
wild type
genome wide
copy number
case report
adipose tissue
skeletal muscle