Potential diagnostic value of CSF metabolism-related proteins across the Alzheimer's disease continuum.

Silvia PaciottiAnna Lidia WojdałaGiovanni BellomoAndrea TojaElena ChipiSander R PiersmaThang V PhamLorenzo GaetaniConnie R JimenezLucilla Parnetti Davide Chiasserini

Published in: Alzheimer's research & therapy (2023)

Our study confirmed the potential role of UCHL1 and FABP3 as neurodegenerative biomarkers for AD. Furthermore, our results validated the increase of PKM activity in CSF of AD patients, already at the preclinical phase of the disease. Increased PKM activity was observed also in FTD patients, possibly underlining similar alterations in energy metabolism in AD and FTD.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
mesenchymal stem cells
drug induced