Impaired Chromatin Remodeling Predicts Better Survival to Modified Gemcitabine and S-1 plus Nivolumab in Advanced Biliary Tract Cancer: A Phase II T1219 Study.

Nai-Jung Chiang Kien Thiam Tan Li-Yuan Bai Chin-Fu Hsiao Chung-Yu Huang Yi-Ping Hung Chien-Jui Huang San-Chi Chen Yan-Shen Shan Yee Chao Yi-Hsiang Huang I-Cheng Lee Pei-Chang Lee Yung-Yeh Su Shu-Jen Chen Chun-Nan Yeh Li-Tzong Chen Ming-Huang Chen

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

NGS is a safe and promising regimen in ABTC. Impaired functions of chromatin remodeling genes may be a potential surrogate biomarker with predictive value in this study.

Keyphrases

phase ii
gene expression
genome wide
clinical trial
dna damage
transcription factor
open label
oxidative stress
young adults
dna methylation
climate change
study protocol
phase iii
placebo controlled