Stability of housekeeping genes in inflamed joints of spontaneous and collagen-induced arthritis in DBA/1 mice.

Celia María Quiñonez-FloresSalma Marcela López-LoezaCésar Pacheco-TenaPerla María Muñoz-MoralesSamara Acosta-JiménezSusana Aideé González-Chávez

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)

This study demonstrates that commonly used reference genes may not be suitable for arthritic tissues from DBA/1 mice, and strengthening the principle that meticulous validation of reference genes is essential before each experiment to obtain valid and reproducible qPCR data for analysis or interpretation.

Keyphrases

genome wide
bioinformatics analysis
genome wide identification
high fat diet induced
gene expression
rheumatoid arthritis
high glucose
genome wide analysis
type diabetes
insulin resistance
oxidative stress
transcription factor
dna methylation
drug induced
machine learning
artificial intelligence
skeletal muscle