Oxidation-Responsive and Aggregation-Induced Emission Polymeric Micelles with Two-Photon Excitation for Cancer Therapy and Bioimaging.
Haiyang HeWeihua ZhuangBoxuan MaXin SuTao YuJun HuLiang ChenRongrong PengGaocan LiYun-Bing WangPublished in: ACS biomaterials science & engineering (2019)
Polymeric micelles with stimuli-triggered drug release and AIE active bioimaging have emerged as potential candidates for theranostics. Herein, a curcumin (Cur) loaded oxidation-responsive mPEG-b-PLG (Se)-TP polymeric micelle system with great aggregation-induced emission (AIE) active and two-photon imaging property has been developed for simultaneous antitumor treatment and bioimaging. Cur-loaded polymeric micelles with a core-shell structure and a homogeneous size of 136 nm show great physiological stability while rapidly disassemble under oxidation environment with accelerated drug release. The excellent biocompatibility and great AIE property and two-photon excitation endow these functional mPEG-b-PLG (Se)-TP micelles as bioprobes for the two-photon imaging of cells and deeper tissues. Furthermore, the biodistribution of nanocarriers and intracellular drug delivery can also be traced. Moreover, the Cur-loaded micelles also show great tumor inhibition ability and minimal side effects in vivo compared with free drug. These novel polymeric micelles are expected to be potential candidates for cancer theranostics.
Keyphrases
- drug delivery
- drug release
- cancer therapy
- living cells
- fluorescent probe
- single molecule
- high resolution
- hydrogen peroxide
- oxidative stress
- monte carlo
- human health
- energy transfer
- gene expression
- emergency department
- photodynamic therapy
- mass spectrometry
- papillary thyroid
- electron transfer
- cell cycle arrest
- squamous cell
- fluorescence imaging
- cell death
- replacement therapy