Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models.
Roberto RuiuChiara CossuAntonella IacovielloLaura ContiElisabetta BolliLuca PonzoneJolanda MagriAlekya RumandlaEnzo CalauttiFederica CavalloPublished in: Journal of experimental & clinical cancer research : CR (2023)
xCT is dispensable for proper immune system function, thus supporting the safety of xCT targeting in oncology. Nevertheless, xCT is involved in several processes required for the metastatic seeding of mammary cancer cells, thus broadening the scope of xCT-targeting approaches.