Landscape of DNA damage response gene alterations in breast cancer: A comprehensive investigation.

Juan JinJianing CaoBin LiTing LiJian ZhangJun CaoMingchun ZhaoLeiping WangBiyun WangZhonghua TaoXi-Chun Hu

Published in: Cancer (2023)

Patients with germline FA mutations more frequently have tumors with somatic DDR mutations. Somatic DDR mutations lead to anticancer immunological phenotypes in BC. No differences in prognosis according to germline or somatic DDR mutations were found.

Keyphrases

dna damage response
copy number
dna repair
genome wide
gene expression
oxidative stress
dna methylation
single cell
dna damage
transcription factor