Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses.
Luanluan SunLisa PennellsStephen KaptogeChristopher P NelsonScott C RitchieGad AbrahamMatthew ArnoldSteven BellThomas BoltonStephen BurgessFrank DudbridgeQi GuoEleni SofianopoulouDavid StevensJohn R ThompsonAdam S ButterworthAngela M WoodJohn DaneshNilesh J SamaniMichael InouyeEmanuele Di AngelantonioPublished in: PLoS medicine (2021)
Our results suggest that addition of PRSs to conventional risk factors can modestly enhance prediction of first-onset CVD and could translate into population health benefits if used at scale.
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