Benzoquinone and furopyridinone derivatives from the marine-derived fungus Talaromyces sp. MCCC 3A01752.

Xuan HongLingzhi TangZhongwei ChenQiliang LaiBeibei ZhangYouwei JiangXunjie WangRuonan HeJianhui LinZongze ShaoShan LinWeiyi Wang

Published in: Natural product research (2022)

Two new compounds, compounds 1 and 2 , were obtained from the culture of a marine-derived fungus Talaromyces sp. MCCC 3A01752, together with 13 known compounds ( 3 - 15 ). Their structures were elucidated based on detailed analysis of NMR, HRESIMS, ECD spectra and OR value. Compound 1 exhibited antibacterial potential against Staphylococcus aureus with a MIC value of 100 μM and cytotoxic activity against gastric cancer cell line MKN1 with a IC 50 value of 78.0 μM.

Keyphrases

staphylococcus aureus
high resolution
magnetic resonance
biofilm formation
anti inflammatory
silver nanoparticles
mass spectrometry
risk assessment
density functional theory