Autophagy-Mediated Inflammatory Cytokine Secretion in Sporadic ALS Patient iPSC-Derived Astrocytes.

null BaofengFengAsiamah Ernest AmponsahRuiyun GuoXin LiuJinyu ZhangXiaofeng DuZijing ZhouJingjing HeJun MaHuixian Cui

Published in: Oxidative medicine and cellular longevity (2022)

Alteration in the mTOR/ULK1/Beclin-1 pathway regulated cytokine secretion in ALS astrocytes, which was able to lead to noncell autonomous toxicity. Autophagy activation mitigated cytokine secretion by ALS astrocytes.

Keyphrases

amyotrophic lateral sclerosis
oxidative stress
cell death
signaling pathway
case report
late onset
transcription factor