Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.

J E SilandB GeelhoedC RoselliB WangH J LinStefan WeissS TrompetM E van den BergE Z SolimanL Y ChenI FordJ W JukemaP W MacfarlaneJ KornejH LinKathryn L LunettaM KavousiJ A KorsM A IkramX GuoJ YaoM DörrS B FelixU VölkerN SotoodehniaD E ArkingB H StrickerSusan R Heckbert Steven A LubitzE J BenjaminAlvaro AlonsoP T EllinorP van der HarstMichiel Rienstra

Published in: PloS one (2022)

For resting heart rates below 65 bpm, our results support an inverse causal association between genetically-determined resting heart rate and incident AF.

Keyphrases

heart rate
atrial fibrillation
heart rate variability
blood pressure
cardiovascular disease
heart failure
oral anticoagulants
left atrial
catheter ablation
left atrial appendage
direct oral anticoagulants
venous thromboembolism
coronary artery disease
acute coronary syndrome
mitral valve