Prognostic Immune Effector Signature in Adult Acute Lymphoblastic Leukemia Patients Is Dominated by γδ T Cells.
Anne CharlotteLe Floch Le FlochMarie-Sarah RouvièreNassim SalemAmira Ben AmaraFlorence OrlanducciNorbert VeyLaurent GorvelAnne-Sophie ChretienDaniel OlivePublished in: Cells (2023)
The success of immunotherapy has highlighted the critical role of the immune microenvironment in acute lymphoblastic leukemia (ALL); however, the immune landscape in ALL remains incompletely understood and most studies have focused on conventional T cells or NK cells. This study investigated the prognostic impact of circulating γδ T-cell alterations using high-dimensional analysis in a cohort of newly diagnosed adult ALL patients (10 B-ALL; 9 Philadelphia + ALL; 9 T-ALL). Our analysis revealed common alterations in CD8 + T cells and γδ T cells of relapsed patients, including accumulation of early stage differentiation and increased expression of BTLA and CD73. We demonstrated that the circulating γδ T-cell signature was the most discriminating between relapsed and disease-free groups. In addition, Vδ2 T-cell alterations strongly discriminated patients by relapse status. Taken together, these data highlight the role of ɣδ T cells in adult ALL patients, among whom Vδ2 T cells may be a pivotal contributor to T-cell immunity in ALL. Our findings provide a strong rationale for further monitoring and potentiating Vδ2 T cells in ALL, including in the autologous setting.
Keyphrases
- newly diagnosed
- acute lymphoblastic leukemia
- end stage renal disease
- early stage
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- stem cells
- acute myeloid leukemia
- patient reported outcomes
- artificial intelligence
- mesenchymal stem cells
- high resolution
- diffuse large b cell lymphoma
- deep learning
- dendritic cells
- platelet rich plasma
- high speed